Design and Synthesis of Novel meta-Diamide Compounds Containing Sulfur Derivatives as Potential Pesticides
DOI: 10.54647/chemistry150376 27 Downloads 900 Views
Author(s)
Abstract
As a typical meta-Diamide (m-diamide) insecticide, Broflanilide is highly effective, exhibits low toxicity, and shows no cross resistance with traditional insecticides that act on the γ-aminobutyric acid (GABA) receptor. As a high halogen content potentially causes risks and was concerning to researchers, easily derivatized sulfur with diverse biological activities was introduced into leading compound based on the principles of the molecular drug design. Fifteen novel sulfur-containing m-amide derivatives, A-F, were synthesized through a series of experiments, and the structures were confirmed by melting point determinations, 1H NMR, 13C NMR and HRMS. The biochemical properties of the compounds were closely related to their structural characteristics. However, the insecticidal activities of the target compounds were lower than expected. Structure-activity relationship (SAR) results revealed that the compounds R1 = CN exhibited better insecticidal activity (D-3, 46.67%; E-3, 50.00%; and F-3, 34.48%) than that of other compounds against Plutella xylostella (P. xylostella) at 500 mg·L-1. These experiments provide a reference for related research on the synthesis and derivatization of sulfur-containing compounds.
Keywords
m-diamine, sulfur, design, synthesis, insecticidal activity
Cite this paper
Yan Zhang, Peixuan Li, Jingwen Wu, Yunyi Tan, Sha Zhou, Jifen Wang,
Design and Synthesis of Novel meta-Diamide Compounds Containing Sulfur Derivatives as Potential Pesticides
, SCIREA Journal of Chemistry.
Volume 9, Issue 2, April 2024 | PP. 30-43.
10.54647/chemistry150376
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