Using chiral magnetic surface molecularly imprinted polymers for chiral separation of gossypol

Volume 4, Issue 4, August 2019     |     PP. 113-123      |     PDF (416 K)    |     Pub. Date: September 6, 2019
DOI:    219 Downloads     7023 Views  

Author(s)

Chen ZHAO, School of Electronic and Information Engineering of Xi'an Technological University, Xi’an City, Shanxi Province, 710021, Peoples Republic of China
Xiang-yan MENG, School of Electronic and Information Engineering of Xi'an Technological University, Xi’an City, Shanxi Province, 710021, Peoples Republic of China
Haixian PAN, School of Electronic and Information Engineering of Xi'an Technological University, Xi’an City, Shanxi Province, 710021, Peoples Republic of China
Guang-feng JIA, School of Electronic and Information Engineering of Xi'an Technological University, Xi’an City, Shanxi Province, 710021, Peoples Republic of China
Wenzong Lu, School of Electronic and Information Engineering of Xi'an Technological University, Xi’an City, Shanxi Province, 710021, Peoples Republic of China

Abstract
The aim of this study was to prepare a method for quick resolution of gossypol. The chiral magnetic surface molecular imprinting polymers (chiral MMIP) were utilized. A chiral reagent (N-octyl-D-glucosamine) acted as a monomer, and magnetic nanoparticles were used as carriers to obtain chiral MMIPs. The chiral MMIPs could combine with (+)-gossypol molecules, and enable the separation of (–)-gossypol from racemic gossypol.The characterization of chiral MMIPs were detected by Infrared spectroscopic analysis and transmission electron microscopic (TEM). The results showed that the presence of monomeric methacrylate in the chiral MMIPs and the particle size of chiral MMIP was about 150 nm. The binding capacity of gossypol chiral MMIP indicated that the chiral MMIPs prepared in the laboratory were capable of binding well to gossypol. The polymer was then used as the stationary phase for column chromatography, and (-)-gossypol solution was thus isolated through chromatography. The product was tested by ultraviolet spectrum and optical rotation tests and was confirmed to be (-)-gossypol. Thus, we established a simple, rapid, and cost-effective method for separating chiral compounds.

Keywords
gossypol; magnetic surface molecularly imprinted polymer; chiral reagent; ultraviolet spectrum

Cite this paper
Chen ZHAO, Xiang-yan MENG, Haixian PAN, Guang-feng JIA, Wenzong Lu, Using chiral magnetic surface molecularly imprinted polymers for chiral separation of gossypol , SCIREA Journal of Chemistry. Volume 4, Issue 4, August 2019 | PP. 113-123.

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